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Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 418-424 doi: 10.1007/s11684-013-0297-8

Abstract:

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated acceleratedremains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immunemodulation have been identified, and the pathways behind the immune-mediated destruction of platelets

Keywords： primary immune thrombocytopenia B lymphocytes T lymphocytes antigen-presenting cells cytokines

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Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 938-941 doi: 10.1007/s11684-021-0895-9

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell phenotype immune activation immune tolerance liver diseases

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Evaluation of power regeneration in primary suspension for a railway vehicle

Ruichen WANG, Zhiwei WANG

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 2, Pages 265-278 doi: 10.1007/s11465-019-0571-9

Abstract: rail vehicles, this study presents the feasibility of using power regenerating dampers (PRDs) in the primaryPRDs are configured as hydraulic electromagnetic-based railway primary vertical dampers and evaluatedof the generator, and the electromagnetic configuration provides a controllable damping force to the primaryIn several case studies, generic railway vehicle primary suspension systems that are configured to includeResults indicate that PRDs can simultaneously replace conventional primary vertical dampers, regenerate

Keywords： railway vehicle primary damper power regeneration ride comfort running safety

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms.

Keywords： DNAH10 mice motile cilia mutation primary ciliary dyskinesia

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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Approach for natural gas to be a primary energy source in China

Weihe HUANG, Jindian CHEN, Chuan FU, Yan HUANG

Frontiers of Engineering Management 2019, Volume 6, Issue 4, Pages 467-476 doi: 10.1007/s42524-019-0068-6

Abstract: In the long-term adjustment of energy structure, natural gas has gradually become the primary energyFor natural gas to be the primary energy, the exploitation of gas resources must be expanded, resource

Keywords： natural gas energy revolution primary energy utilization areas approaching means

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Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract:

Primary hepatic carcinoma (PHC) is a common malignant tumor in China.systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary

Keywords： traditional Chinese medicine primary hepatic carcinoma meta-analysis

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune

Keywords： hyperthermia HPV immune response virus tumor

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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully

Keywords： SARS-CoV-2 COVID-19 vaccine immune escape breakthrough prevention

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneHowever, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Approximately 80% of patients do not respond appropriately because of primary or acquired therapeuticAlong with the characterization of more immune checkpoints, the combinatory treatment of multi-immune

Keywords： immune checkpoints multi-target immune escape immune-related adverse events combination therapy